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Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review.

Department of Endocrinology and Metabolism, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan. Department of Nephrology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan. Department of Respiratory Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan. Department of Neurology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan. Department of Radiology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan. Department of Emergency and Critical Care Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.

Internal medicine (Tokyo, Japan). 2017;(15):1993-1999
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Abstract

A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seizure (ASS), patients with ketotic hyperglycemia develop ASS less frequently. In this T1D case with CKD, severe hyperglycemia in conjunction with other metabolic insults, such as uremia, hyponatremia, and hypocalcemia, probably provoked his seizure despite the severe ketonemia.

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Publication Type : Case Reports ; Review

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